[Bone-derived hormones and their systemic regulation.]
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Updated: Feb 16, 2026

Bone Marrow-derived Macrophage Production
Published on: November 22, 2013
Yuichi Takashi1, Seiji Fukumoto1, Toshio Matsumoto1
1Fujii Memorial Institute of Medical Sciences, Tokushima University, Japan.
Abstract:
Bone has several functions such as supporting our body, protecting internal organs and contributing to hematopoiesis. Recently, it has been revealed that bone also works as an endocrine tissue and systemically regulates functions of other organs. It has been reported that fibroblast growth factor 23(FGF23)regulates phosphate metabolism and osteocalcin affect glucose/energy metabolism. In addition, sclerostin, interleukin-11(IL-11)and lipocalin 2 have been also found to be bone-derived humoral factors. Further investigation concerning the network systems among multiple organs via bone-derived hormones may lead to the development of new drugs.
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