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Published on: November 22, 2013
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[Bone-derived hormones and their systemic regulation.]
Yuichi Takashi1, Seiji Fukumoto1, Toshio Matsumoto1
1Fujii Memorial Institute of Medical Sciences, Tokushima University, Japan.
Clinical Calcium
|December 28, 2017
Summary
Bone functions beyond support and protection, acting as an endocrine tissue. Bone-derived hormones like fibroblast growth factor 23 (FGF23) and osteocalcin regulate systemic functions, offering potential for new drug development.
Area of Science:
- Endocrinology
- Bone Biology
- Metabolic Regulation
Background:
- Bone traditionally viewed for structural and hematopoietic roles.
- Emerging evidence highlights bone's function as an endocrine organ.
- Several bone-derived factors are known to influence systemic physiology.
Purpose of the Study:
- To explore the endocrine functions of bone.
- To identify key bone-derived hormones and their systemic effects.
- To investigate the potential of bone-derived factors in therapeutic development.
Main Methods:
- Literature review of bone endocrine functions.
- Analysis of known bone-derived humoral factors.
- Exploration of inter-organ regulatory networks mediated by bone hormones.
Main Results:
- Fibroblast growth factor 23 (FGF23) regulates phosphate metabolism.
- Osteocalcin influences glucose and energy metabolism.
- Sclerostin, interleukin-11 (IL-11), and lipocalin 2 are identified as bone-derived factors.
Conclusions:
- Bone acts as a critical endocrine tissue.
- Bone-derived hormones play significant roles in systemic regulation.
- Understanding these networks may facilitate novel drug discovery.
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