[Cellular metabolite controls oxidative stress resistance.]
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Updated: Feb 16, 2026

Measuring Oxidative Stress Resistance of Caenorhabditis elegans in 96-well Microtiter Plates
Published on: May 9, 2015
1Cellular Memory Laboratory, RIKEN, Saitama, Japan.
Abstract:
Cellular metabolites such as acetylcoenzyme A and nicotinamide adenine dinucleotide control gene transcription via modulating the reader or eraser protein in histone modification. A ketone body, D-β-hydroxybutyrate is an endogenous metabolite which has been reported as a class Ⅰ histone deacetylases(HDACs). In this chapter, a molecular basis of the ketone body in transcriptional control and protection against oxidative stress is reviewed and discussed.
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