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Updated: Feb 16, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
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Pathophysiology of the underactive bladder.

Naoki Aizawa1, Yasuhiko Igawa1

  • 1Department of Continence Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Investigative and Clinical Urology
|December 28, 2017
PubMed
Summary
This summary is machine-generated.

Underactive bladder (UAB) involves difficulty emptying the bladder due to detrusor underactivity. This review explores UAB causes and pathophysiology, highlighting remaining uncertainties needing further research.

Keywords:
AgingDenervationDiabetic neuropathiesIschemiaUrinary bladder diseases

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Area of Science:

  • Urology
  • Physiology

Background:

  • Underactive bladder (UAB) is a condition characterized by prolonged urination, hesitancy, and a slow stream, often with storage symptoms.
  • It is linked to factors like aging, diabetes, neurological disorders, and nerve injury.

Purpose of the Study:

  • To review and describe the relationships between contributing factors and the pathophysiology of UAB.
  • To identify remaining uncertainties in UAB pathophysiology.

Main Methods:

  • Literature review of previous reports on UAB.
  • Analysis of contributing factors and their link to detrusor underactivity.

Main Results:

  • Identified potential causes including myogenic failure, efferent/afferent dysfunctions, and central nervous system dysfunction.
  • Established links between various factors and the development of UAB.

Conclusions:

  • While several factors are associated with UAB, its pathophysiology remains incompletely understood.
  • Further investigation using animal models is necessary to clarify remaining pathophysiological uncertainties.