Related Experiment Video

Updated: Feb 16, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

4.1K

SUOX is negatively associated with multistep carcinogenesis and proliferation in oral squamous cell carcinoma

Ken Nakamura1,2, Jun Akiba3,4, Sachiko Ogasawara1

  • 1Department of Pathology, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Japan.

Medical Molecular Morphology
|December 28, 2017
PubMed

Insights

Sulfite oxidase (SUOX) expression decreases during oral cancer development. Lower SUOX levels correlate with advanced tongue cancer, suggesting SUOX is a key molecule in oral squamous cell carcinoma progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Oral squamous cell carcinoma (OSCC) is a prevalent head and neck malignancy.
  • Understanding the molecular mechanisms driving OSCC is crucial for developing effective therapies.

Purpose of the Study:

  • To identify key molecules and elucidate molecular mechanisms in OSCC carcinogenesis.
  • To investigate the role of Sulfite oxidase (SUOX) in the development of oral cancer.

Main Methods:

  • Microarray analysis of RNA from normal epithelium, dysplasia, and OSCC.
  • Protein level evaluation of SUOX expression in 58 tongue cancer patients.
  • Correlation analysis with clinicopathological factors.

Main Results:

  • SUOX gene expression showed a stepwise decrease from normal to dysplastic to cancerous tissues.
  • SUOX protein expression significantly declined with OSCC progression.
  • Lower SUOX expression was associated with higher T classification in OSCC.

Conclusions:

  • SUOX expression is significantly reduced during oral carcinogenesis.
  • SUOX negatively correlates with the progression and proliferation of tongue cancer.
  • SUOX may serve as a potential biomarker or therapeutic target in OSCC.
Keywords:
CarcinogenesisDysplasiaImmunohistochemistryMicroarrayOral squamous cell carcinomaSulfite oxidase

More Related Videos

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma12:03

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Published on: July 25, 2011

20.0K
Development of Compendium for Esophageal Squamous Cell Carcinoma03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

860

Related Concept Videos

Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.2K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.6K
Oral Cavity01:11

Oral Cavity

The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
3.2K
Positive, Negative, and Zero Work00:58

Positive, Negative, and Zero Work

Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.3K
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
653