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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Jan 3, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

274

Does azithromycin given to women in labour decrease ocular bacterial infection in neonates? A double-blind,

Sarah E Burr1, Bully Camara2, Claire Oluwalana2

  • 1London School of Hygiene and Tropical Medicine, London, UK.

BMC Infectious Diseases
|December 29, 2017
PubMed
Summary
This summary is machine-generated.

Administering oral azithromycin to women during labor may reduce bacterial neonatal conjunctivitis. This intervention showed a lower incidence of bacterial and gram-positive infections in newborns.

Keywords:
AzithromycinConjunctivitisLabourNeonateRandomized trial

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Area of Science:

  • Neonatal Health
  • Infectious Diseases
  • Pharmacology

Background:

  • Vertical transmission of bacterial pathogens can lead to neonatal infections, including bacterial conjunctivitis.
  • Preventing mother-to-infant transmission is crucial for reducing neonatal infections.

Purpose of the Study:

  • To assess the effect of single-dose oral azithromycin in laboring women on neonatal bacterial colonization.
  • To evaluate the reduction in purulent neonatal conjunctivitis as a secondary objective.

Main Methods:

  • A double-blind, randomized trial was conducted.
  • Ocular samples were collected from neonates with suspected purulent conjunctivitis within eight weeks of birth.
  • Bacterial infection was confirmed using PCR.

Main Results:

  • The overall incidence of purulent conjunctivitis did not significantly differ between azithromycin and placebo groups.
  • However, the incidence of purulent conjunctivitis due to bacterial infection was significantly lower in the azithromycin arm (1.2% vs. 3.8%).
  • Incidence of gram-positive bacterial infections was also reduced in the azithromycin group (1.0% vs. 3.3%).

Conclusions:

  • Oral azithromycin administered to women during labor shows potential in decreasing bacterial neonatal conjunctivitis.
  • The findings suggest a possible preventative role for azithromycin in specific bacterial neonatal infections.