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Network Covalent Solids02:18

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Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
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Designing Silk-silk Protein Alloy Materials for Biomedical Applications
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Covalent Organic Frameworks: From Materials Design to Biomedical Application.

Fuli Zhao1,2, Huiming Liu3, Salva D R Mathe4

  • 1Department of Polymer Science and Technology and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. zhaofuli@tju.edu.cn.

Nanomaterials (Basel, Switzerland)
|December 29, 2017
PubMed
Summary

Covalent organic frameworks (COFs) are novel porous polymers with tunable properties. These materials show great promise for drug delivery, bioimaging, and theranostics in human healthcare.

Keywords:
biomedical applicationcovalent organic frameworks (COFs)drug deliverydynamic covalent bondsnanomedicine

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Polymer Chemistry

Background:

  • Covalent organic frameworks (COFs) are crystalline porous polymers composed of light elements linked by dynamic covalent bonds.
  • COFs offer unique features like large surface area, tunable porosity, and excellent crystallinity, surpassing conventional materials.

Purpose of the Study:

  • To review the evolution, synthesis, design, and functionalization of COFs.
  • To highlight recent advances in COFs for biomedical and pharmaceutical applications.
  • To discuss the future challenges and opportunities of COFs in healthcare.

Main Methods:

  • Tracing the evolution of COFs based on their linkages.
  • Analyzing synthetic methodologies and structural design principles.
  • Summarizing recent research on COF applications in biomedicine.

Main Results:

  • COFs exhibit tunable porosity and photoelectric properties, making them suitable for drug delivery, bioimaging, biosensing, and theranostics.
  • Advances in synthetic methods and functionalization enhance COF performance for biomedical applications.
  • COFs demonstrate significant potential for addressing future challenges in human healthcare.

Conclusions:

  • COFs represent an innovative class of materials with broad potential in biomedical and pharmaceutical fields.
  • Despite being in early stages, COFs offer a promising new avenue for disease theranostics and human healthcare.
  • Further research into COF synthesis, design, and functionalization will unlock their full therapeutic potential.