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Altered Long Non-Coding RNA Transcriptomic Profiles in Ischemic Stroke.

Wenzhen He1, Duncan Wei2, De Cai2

  • 11 Department of Neurology, First Affiliated Hospital of Shantou University Medical College , Shantou, China .

Human Gene Therapy
|December 30, 2017
PubMed
Summary
This summary is machine-generated.

This study identifies long non-coding RNAs (lncRNAs) in ischemic stroke patients, revealing their potential roles in stroke pathophysiology and offering new diagnostic targets. These findings advance understanding of lncRNA involvement in stroke.

Keywords:
co-expressionischemic strokelncRNA profilingmRNA profiling

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Area of Science:

  • Genomics
  • Molecular Biology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are known regulators in ischemic stroke.
  • The role of long non-coding RNAs (lncRNAs) in ischemic stroke pathophysiology remained largely uncharacterized.

Purpose of the Study:

  • To identify lncRNA profiles in ischemic stroke patients.
  • To elucidate the regulatory mechanisms of lncRNAs in stroke pathophysiology.

Main Methods:

  • RNA sequencing was performed on blood samples from ischemic stroke patients and healthy controls.
  • Differential expression analysis identified differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs).
  • Co-expression networks and miRNA-lncRNA-mRNA interaction networks were constructed and validated using Gene Expression Omnibus data.

Main Results:

  • 61 DElncRNAs and 673 DEmRNAs were identified.
  • LOC105372881 and LOC101929707 were the most significantly altered lncRNAs.
  • DElncRNAs may regulate pathways including glycolysis/gluconeogenesis and hematopoietic cell lineage.
  • Expression of six DElncRNAs and eleven DEmRNAs was validated using GSE22255 data.

Conclusions:

  • This is the first study to identify blood lncRNAs in human ischemic stroke using RNA sequencing.
  • The identified lncRNAs and their regulatory networks provide a foundation for understanding lncRNA roles in ischemic stroke.
  • These findings may lead to novel diagnostic biomarkers and therapeutic strategies for ischemic stroke.