Related Experiment Video For X-linked adrenoleukodystrophy
Updated: Feb 16, 2026

Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
Autonomic dysfunction in a patient with X-linked adrenoleukodystrophy
Yifan Zhang1, Dongmei Guo1, Yi Tang1
1a Department of Neurology, Xuan Wu Hospital , Capital Medical University , Beijing , P. R. China.
Abstract:
X-linked adrenoleukodystrophy is an inherited disease caused by abnormal accumulation of very long chain fatty acids. The diagnosis of X-linked adrenoleukodystrophy can be confirmed with the mutation of ABCD1 gene. The main symptom of the X-linked adrenoleukodystrophy is spastic paraparesis, and autonomic dysfunction is rare in X-linked adrenoleukodystrophy. Here, we presented an X-ALD case of a 46-year-old Asian male with severe autonomic dysfunction. Impairment of the autonomic nervous system may closely relate to mitochondrial defect.
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