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Updated: Feb 16, 2026

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
Published on: January 7, 2019
Enhanced Differentiation of Human Preosteoblasts on Electrospun Blend Fiber Mats of Polydioxanone and Anionic
Nowsheen Goonoo1,2, Archana Bhaw-Luximon2, Ulrich Jonas3
1Physical Chemistry I, Department of Chemistry and Biology & Research Center of Micro and Nanochemistry and Engineering (Cμ), University of Siegen, Adolf-Reichwein-Strasse 2, 57076 Siegen, Germany.
Abstract:
The viability and differentiation of SaOS-2 preosteoblasts on fiber mats of blends comprising of the biodegradable poly(ester-ether) polydioxanone (PDX) and the sulfate-containing anionic polysaccharides kappa-carrageenan (KCG) and fucoidan (FUC) were investigated for a range of different blend compositions. The detailed analysis of the blend nanofiber properties revealed a different degree of miscibility of PDX and the polysaccharide leading to a different enrichment at the surface of the blend nanofibers, which were observed to be stable in phosphate buffer solution (PBS) for up to 5 weeks. The fibrous mats of PDX/FUC led to the highest osteogenic differentiation with very good cell viability. The electrospun blend fibers also supported human-induced pluripotent stem (iPS) cells and iPS cell-derived embryoid bodies with high cell viability, which underlines the potential of these novel blend fiber systems for optimized performance in bone tissue engineering applications.
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