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[Research progress on tranexamic acid application strategy in total knee arthroplasty]

Jian-Jun Ji1, Zi-Quan Yang2, Yong-Liang Zhao1

  • 1Department of Orthopaedics, the Second Hospital Affiliated to Shanxi Medical Univeristy, Taiyuan 030001, Shanxi, China.

Zhongguo Gu Shang = China Journal of Orthopaedics and Traumatology
|December 30, 2017
PubMed

Tranexamic acid(TXA) as an antifibrinolytic drugs used to reduce the total knee arthroplasty(TKA) postoperative blood loss is a hot issue in recent years. Such as blood loss, hemoglobin, transfusion rate and other relevant indexs effected by the impact of total knee replacement have been studied and investigated by many scholars. There is no a gold standard about how to safely and effectively apply the TXA. Depending on the dose, TXA may be used by body weight or using 1.5 g or 3.0 g directly. Depending on the different route of administration, TXA may be intravenous infusion, topical application and oral medication. Depending on the using opportunity, TXA can be used preoperative, intraoperative, postoperative or combined application with different times. Without any increase in the chances of thrombosis after TKA, choosing the more scientific instructions to play the greatest utility TXA is a hot issue recently.

Keywords:
Application strategyArthroplasty, replacement, kneeThrombosisTranexamic acid

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