Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induced-fit Model01:13

Induced-fit Model

89.7K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
89.7K
Protection of Alcohols02:31

Protection of Alcohols

8.1K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.1K
Zones of Protection01:16

Zones of Protection

821
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
821
Traumatic Memory01:20

Traumatic Memory

597
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
597
Protecting Self-Esteem01:27

Protecting Self-Esteem

238
Self-esteem, a central component of psychological well-being, is actively maintained through various cognitive and behavioral strategies. Individuals employ specific mechanisms to preserve a positive self-concept and mitigate threats to their self-worth, particularly in contexts involving social evaluation or personal feedback. Four primary techniques are commonly used to sustain self-esteem.Manipulating AppraisalsOne prominent strategy involves manipulating appraisals from others. Individuals...
238
Radial System Protection01:23

Radial System Protection

448
Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
448

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Socioeconomic differences in the prevalence, treatment and control of major cardiometabolic risk factors by sex: a cross-sectional study of the UK Biobank.

BMJ public health·2026
Same author

Blood pressure parameters and cognitive decline and dementia after stroke or transient ischemic attack: results from the PROGRESS trial.

American journal of hypertension·2026
Same author

Blood pressure lowering for the prevention of REcurrent stroke and Cardiovascular outcomes After acute intracerebral haemorrhage: protocol for an individual Participant data meta-analysis of randomised controlled trials (RECAP-ICH).

Cerebrovascular diseases (Basel, Switzerland)·2026
Same author

Relationship between hypertensive disorders of pregnancy and postpartum mood and anxiety symptoms: P4 study.

Archives of women's mental health·2026
Same author

Sex differences in multimorbidity: a systematic review and meta-analysis.

BMC public health·2026
Same author

Wake-active brainstem GABA neurons signal sleep pressure by upregulating AMPA receptors to drive recovery sleep.

Current biology : CB·2026

Related Experiment Video

Updated: Feb 16, 2026

A Novel In Vitro Model of Blast Traumatic Brain Injury
08:59

A Novel In Vitro Model of Blast Traumatic Brain Injury

Published on: December 21, 2018

11.2K

Xenon Protects against Blast-Induced Traumatic Brain Injury in an In Vitro Model.

Rita Campos-Pires1,2, Mariia Koziakova1,2, Amina Yonis1

  • 11 Anaesthetics, Pain Medicine and Intensive Care Section, Department of Surgery and Cancer, Imperial College London , London, United Kingdom .

Journal of Neurotrauma
|December 30, 2017
PubMed
Summary

Xenon gas shows neuroprotective effects against blast-induced traumatic brain injury (TBI). This study found xenon treatment reduced injury in brain slices, suggesting it may be a potential first-line TBI treatment.

Keywords:
TBIblast traumatic brain injuryblast-induced neurotraumaneuroprotectionprimary blast injuryxenon

More Related Videos

Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents
06:09

Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents

Published on: November 6, 2020

3.1K
Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

11.4K

Related Experiment Videos

Last Updated: Feb 16, 2026

A Novel In Vitro Model of Blast Traumatic Brain Injury
08:59

A Novel In Vitro Model of Blast Traumatic Brain Injury

Published on: December 21, 2018

11.2K
Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents
06:09

Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents

Published on: November 6, 2020

3.1K
Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

11.4K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Trauma Research

Background:

  • Blast-induced traumatic brain injury (TBI) is a significant concern, particularly with increasing global conflicts.
  • Current treatments for blast-TBI are limited, necessitating novel therapeutic strategies.
  • Understanding the mechanisms of secondary injury development post-blast is crucial for effective intervention.

Purpose of the Study:

  • To evaluate the neuroprotective efficacy of xenon as a treatment for blast-induced TBI.
  • To establish and utilize a novel in vitro model for blast-TBI research.
  • To investigate the impact of xenon on both initial and secondary injury progression.

Main Methods:

  • Development of an in vitro organotypic hippocampal brain-slice culture model.
  • Simulation of open-field explosive blast shockwaves using a shock tube generator.
  • Quantification of injury using propidium iodide fluorescence and cleaved caspase-3 immunofluorescence.
  • Administration of 50% xenon 1 hour post-blast exposure.

Main Results:

  • Blast shockwave exposure caused significant injury, increasing with peak-overpressure and impulse.
  • Secondary injury developed up to 72 hours post-trauma, involving apoptotic cell death.
  • Xenon treatment significantly reduced injury at 24, 48, and 72 hours post-blast.
  • Xenon-treated slices showed no significant difference from uninjured controls at 24 and 72 hours.

Conclusions:

  • Xenon demonstrates significant neuroprotective effects in an in vitro blast-TBI model.
  • Xenon treatment reduces initial blast injury and prevents subsequent injury development.
  • Xenon is a promising potential first-line therapeutic agent for blast-induced TBI.