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Vitamin D Deficiency Associated with Differentiated Thyroid Carcinoma: A Case- Control Study
Zahra Heidari1, Mahdi Nikbakht, Mohammad Ali Mashhadi
1Department of Endocrinology and Metabolism, Zahedan University of Medical Sciences, Zahedan, Iran.
Asian Pacific Journal of Cancer Prevention : APJCP
|December 30, 2017
Summary
Vitamin D deficiency is significantly associated with differentiated thyroid cancer. This case-control study found lower vitamin D levels in thyroid cancer patients compared to healthy controls, suggesting a potential link.
Area of Science:
- Endocrinology
- Oncology
- Nutritional Science
Background:
- Global incidence of thyroid cancer has risen in recent decades.
- The role of vitamin D deficiency in this increase remains unclear.
- Investigating potential links between vitamin D levels and thyroid cancer is crucial.
Purpose of the Study:
- To examine the association between vitamin D deficiency and differentiated thyroid cancer.
- To compare serum vitamin D levels in thyroid cancer patients and healthy controls.
Main Methods:
- A case-control study involving 85 differentiated thyroid cancer patients and 85 matched healthy controls.
- Serum vitamin D levels were measured before thyroidectomy.
- Thyroid function, antibodies, and sonography were assessed in all participants.
Main Results:
- The mean serum vitamin D level was significantly lower in the thyroid cancer group (8.00 ±3.7) compared to the control group (13.4 ±7.90).
- A significant association was found between vitamin D deficiency and differentiated thyroid cancer (OR: 6, P=0.046).
- The majority of patients in the case group were female (85%).
Conclusions:
- A significant association exists between vitamin D deficiency and differentiated thyroid cancer.
- Further prospective studies are needed to elucidate the role of vitamin D in thyroid cancer.
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