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The Nucleosome Core Particle

The Nucleosome Core Particle

Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...

The Nucleosome Core Particle

The Nucleosome Core Particle

Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...

What are Lipids?

What are Lipids?

What are Lipids?

What are Lipids?

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Related Experiment Video

Updated: Feb 16, 2026

Triplet Fusion Upconversion Nanocapsule Synthesis

Triplet Fusion Upconversion Nanocapsule Synthesis

Published on: September 7, 2022

Hydroxycinnamic acids loaded in lipid-core nanocapsules.

Giuseppe Granata¹, Grazia M L Consoli¹, Raffaella Lo Nigro²

¹Istituto Chimica Biomolecolare - C.N.R., Via Paolo Gaifami 18, 95126, Italy.

|December 31, 2017

Summary

This summary is machine-generated.

Hydroxycinnamic acids (HAs) were encapsulated in biodegradable nanocapsules to enhance their delivery. These lipid-core nanocapsules protect HAs in the stomach and release them in the intestine for functional foods.

Keywords:

Bioactive polyphenols Hydroxycinnamic acids Lipid-core nanocapsules Nutraceuticals Poly(ε-caprolactone)

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Published on: June 1, 2021

Area of Science:

Food Science
Nanotechnology
Biochemistry

Background:

Hydroxycinnamic acids (HAs) are bioactive polyphenols found in plants and diet.
HAs possess properties beneficial for preventing diseases linked to oxidative stress.
Their application in nutraceuticals is promising but limited by bioaccessibility.

Purpose of the Study:

To enhance the bioaccessibility of hydroxycinnamic acids (HAs).
To develop a delivery system for HAs using lipid-core nanocapsules (NCs).
To evaluate the stability and release profile of encapsulated HAs.

Main Methods:

Encapsulation of HAs in poly(ε-caprolactone) based lipid-core nanocapsules.
Characterization of HA-loaded nanocapsules (HA-NCs) for size, encapsulation efficiency, and stability.
In vitro assessment of HA release under simulated gastric and intestinal conditions.

Main Results:

HA-NCs exhibited a diameter of 224-253 nm with an encapsulation efficiency of 53-78%.
The nanocapsules demonstrated stability over a 30-day period.
In vitro tests confirmed HA preservation in simulated gastric fluid and release in simulated intestinal fluid.

Conclusions:

Biodegradable poly(ε-caprolactone) nanocapsules effectively encapsulate hydroxycinnamic acids.
The developed delivery system enhances HA stability and controls release for improved bioaccessibility.
This system holds potential for creating innovative functional foods with enhanced nutraceutical properties.