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Updated: Feb 16, 2026

Triplet Fusion Upconversion Nanocapsule Synthesis
Published on: September 7, 2022
Hydroxycinnamic acids loaded in lipid-core nanocapsules
Giuseppe Granata1, Grazia M L Consoli1, Raffaella Lo Nigro2
1Istituto Chimica Biomolecolare - C.N.R., Via Paolo Gaifami 18, 95126, Italy.
Abstract:
Ferulic, caffeic, sinapic, and coumaric acids, belonging to the class of hydroxycinnamic acids (HAs), are bioactive polyphenols widespread in the plant kingdom and present in the human diet. Due to their biological properties and effects in the prevention of various diseases associated with oxidative stress, HAs can be exploited for attractive nutraceutical applications. Starting from this and in order to increase bioaccessibility, we encapsulated HAs in lipid-core nanocapsules (NCs) based on a biodegradable and biocompatible poly(ε-caprolactone) polymer. The results showed that nanoparticles loaded with hydroxycinnamic acids (HA-NCs) have diameter of 224-253 nm, encapsulation efficiency of 53-78%, and are stable over time (30 days). In vitro tests evidenced that NCs are able to preserve HAs in the gastric simulated fluid and release them in the intestinal simulated fluid. The delivery system developed could be employed to create novel functional foods.
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