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Atorvastatin combined with ticagrelor prevent ischemia-reperfusion induced vascular endothelial dysfunction in

Stefan Weisshaar1, Brigitte Litschauer1, Tillmann Kerbel1

  • 1Department of Clinical Pharmacology, Medical University of Vienna, Austria.

International Journal of Cardiology
|December 31, 2017
PubMed

Insights

High-dose atorvastatin and ticagrelor prevent endothelial dysfunction from ischemia-reperfusion injury in humans. This combination therapy normalized forearm blood flow responses, showing significant benefits in vascular health.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Tissue injury prevention by atorvastatin and ticagrelor observed in animal studies.
  • Human efficacy of these drugs against endothelial dysfunction post-ischemia-reperfusion (IR) injury remains unclear.

Purpose of the Study:

  • To investigate the effects of high-dose atorvastatin combined with ticagrelor loading on endothelial dysfunction in a human forearm IR injury model.

Main Methods:

  • Randomized, placebo-controlled, double-blinded trial with 32 healthy subjects.
  • Forearm blood flow (FBF) assessed using acetylcholine (endothelium-dependent) and glyceryltrinitrate (endothelium-independent) before and after ischemia-reperfusion.
  • Intervention involved 14 days of 80mg atorvastatin or placebo, followed by a 180mg ticagrelor loading dose.

Main Results:

  • Ticagrelor loading mitigated ischemia-induced endothelial dysfunction.
  • Atorvastatin plus ticagrelor completely normalized the acetylcholine-induced FBF response during reperfusion (P=0.001).
  • Atorvastatin significantly reduced LDL cholesterol; no changes in HDL or triglycerides.

Conclusions:

  • Chronic atorvastatin treatment with ticagrelor loading effectively prevents endothelial dysfunction following acute forearm ischemia in humans.
  • Ticagrelor alone partially mitigated the impaired endothelium-dependent FBF response compared to no intervention.
Abstract

Keywords:
AtorvastatinForearm blood flowIschemia-reperfusion injuryTicagrelor

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