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Anticancer activity of Schiff base-Poloxamer P85 combination against kidney cancer

Ayşegül Doğan1,2, Selami Demirci3,4, Dilek Telci3

  • 1Genetics and Bioengineering Department, Faculty of Engineering, Yeditepe University, Kayisdagi, Istanbul, Turkey. aguldgn@gmail.com.

International Urology and Nephrology
|December 31, 2017
PubMed
Abstract

Insights

A novel copper-manganese complex (SB) combined with pluronic P85 demonstrates significant anticancer effects against renal cell carcinoma (RCC). This SB-P85 combination effectively reduced tumor growth and increased cancer cell death in preclinical models.

Area of Science:

  • Oncology
  • Materials Science
  • Pharmacology

Background:

  • Renal cell carcinoma (RCC) is the predominant form of kidney cancer, with limited effective therapeutic options.
  • The need for novel and alternative treatment strategies for RCC is critical due to insufficient current therapies.

Purpose of the Study:

  • To investigate the anticancer activity of a novel heterodinuclear Cu(II)-Mn(II) complex (Schiff base-SB) in combination with pluronic P85 against RCC.
  • To evaluate the efficacy of the SB-P85 combination in preclinical models of renal cell carcinoma.

Main Methods:

  • In vitro assessment of SB-P85 combination on Renca cells, including cell viability, apoptosis, and gene expression analysis.
  • In vivo evaluation using a Renca-injected BALB/c mouse model to mimic early-stage RCC.

Main Results:

  • The SB-P85 combination significantly decreased Renca cell proliferation by enhancing apoptotic gene expression and inducing apoptosis.
  • In vivo studies showed that SB-P85 treatment suppressed tumor formation and growth in a murine model of RCC.

Conclusions:

  • The SB-P85 combination exhibits promising anticancer activity against renal cell carcinoma.
  • This novel complex holds potential as a therapeutic agent for RCC treatment.
Keywords:
ChemotherapyP85PluronicRenal cell carcinomaSchiff base

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