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Updated: Feb 16, 2026

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
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Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro

Published on: November 26, 2018

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First-line treatment with bendamustine and rituximab, in patients with intermediate-/high-risk splenic marginal zone

Roberto Castelli1, Luigi Bergamaschini2, Giorgio Lambertenghi Deliliers3

  • 1Luigi Sacco Department of Biomedical and Clinical Sciences, University of Milan, Luigi Sacco Hospital Milan, 20157, Milan, Italy. roberto.castelli@unimi.it.

Medical Oncology (Northwood, London, England)
|December 31, 2017
PubMed

Splenic marginal zone lymphomas (SMZLs) are rare indolent B cell neoplasms that affect the spleen, bone marrow, and blood. Although they have an indolent course in the majority of patients, who have a median survival of 8-10 years, ∼ 30% may experience a worse outcome. The prognostic criteria of progression are lymph node and extra-nodal involvement, high lymphocyte counts, anaemia, and thrombocytopenia. The treatment of SMZLs include a "wait and watch strategy", splenectomy, and alkylating agents ± rituximab. We here describe data relating to 70 patients with intermediate-/high-risk SMZLs, who received rituximab/bendamustine as first-line treatment for a median of 60 days (range 1-75) after diagnosis. Sixty patients (86%) achieved a complete response (CR), and seven (10%) a partial response (PR). Three patients (4.3%) experienced disease progression (PD). The median duration of remission was 18 months. Side effects were generally mild. Our findings suggest that rituximab/bendamustine is a feasible treatment option in patients with intermediate-/high-risk SMZLs.

Keywords:
BendamustineIndolent lymphoproliferative diseaseIntermediate-/high-risk patientsRituximabSplenic marginal zone lymphoma (SMZL)

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