Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.8K
Genetics of Speciation02:16

Genetics of Speciation

22.0K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
22.0K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K
What is Population Genetics?01:25

What is Population Genetics?

65.0K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.0K
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

31.2K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
31.2K
Associative Learning01:27

Associative Learning

1.5K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Landscape of copy number variants in Spanish people with dementia.

NPJ genomic medicine·2026
Same author

Challenges in accurate HDV RNA quantification: inter-assay variability and the impact of thermal shock.

Journal of clinical microbiology·2025
Same author

First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia.

Gut·2025
Same author

Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer's Disease in European Populations: Development and Validation.

medRxiv : the preprint server for health sciences·2025
Same author

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations.

Nature genetics·2025
Same author

Progression towards microelimination of hepatitis B virus infection among people living with HIV in Spain.

Enfermedades infecciosas y microbiologia clinica (English ed.)·2025
Same journal

Tracking Synthetic Adhesins on Bacterial Surfaces with Immunofluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Post-Selection Methods for Analyzing mRNA Display Selections and Optimization of Hits.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

High-Performance Computing in Tandem Mass Spectrometry (MS/MS) Peptide Identification.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Engineering and Adapting Disulfide-Containing Proteins to Enable Intracellular Functionality.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

AI-Driven Protein Research: From Prediction to Design.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for the In Vitro Selection of Protein and Peptide Libraries Using mRNA Display.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Related Experiment Video

Updated: Feb 16, 2026

Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium
07:20

Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium

Published on: April 9, 2019

9.8K

Genetic Association Studies in Host-Pathogen Interaction Analysis.

Jose Luis Royo1, Luis Miguel Real2

  • 1Departamento de Bioquímica, Biología Molecular e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain. jlroyo@uma.es.

Methods in Molecular Biology (Clifton, N.J.)
|December 31, 2017
PubMed
Summary
This summary is machine-generated.

Genetic association studies offer a novel way to understand host-pathogen interactions. This approach uses natural genetic diversity to identify key genes influencing infection outcomes, bypassing complex traditional methods.

Keywords:
Association studyCase–control studyHost–pathogen geneticsStudy design

More Related Videos

Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions
07:35

Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions

Published on: July 10, 2021

7.8K
High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

4.8K

Related Experiment Videos

Last Updated: Feb 16, 2026

Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium
07:20

Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium

Published on: April 9, 2019

9.8K
Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions
07:35

Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions

Published on: July 10, 2021

7.8K
High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

4.8K

Area of Science:

  • Host-pathogen interactions
  • Human genetics
  • Population genetics

Background:

  • Molecular-level study of host-pathogen interactions is technically challenging.
  • Traditional methods require complex molecular tools and animal models.
  • Existing approaches are often costly and time-consuming.

Purpose of the Study:

  • To present a complementary approach for studying host-pathogen interactions.
  • To leverage natural interindividual genetic diversity.
  • To identify genetic variants affecting human susceptibility or resistance to pathogens.

Main Methods:

  • Application of genetic association studies.
  • Planning, execution, and analysis of population-based studies.
  • Utilizing natural human genetic variation.

Main Results:

  • Genetic association studies can identify alleles involved in infection progression or resistance.
  • This strategy can reveal new molecular pathways in host-pathogen interactions.
  • The approach provides a framework for population-based genetic studies.

Conclusions:

  • Genetic association studies offer a powerful alternative for unraveling host-pathogen interactions.
  • This method can identify genetic factors influencing disease outcomes.
  • The proposed strategy facilitates the discovery of novel molecular mechanisms.