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Updated: Feb 16, 2026
10:35
An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
Published on: November 28, 2010
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Prognostic indicators in ovarian serous borderline tumours
Anais Malpica1, Teri A Longacre2
1Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Pathology
|January 1, 2018
Summary
Most serous borderline tumors have a good prognosis, but extraovarian disease predicts progression to carcinoma. A proposed pathway links borderline tumors to low-grade serous carcinoma via shared mutations.
Area of Science:
- Gynecologic Oncology
- Pathology
- Molecular Biology
Background:
- Serous borderline tumors (SBTs) of the pelvis generally have a favorable prognosis.
- However, recurrences and progression to carcinoma can occur, often after a prolonged period.
Purpose of the Study:
- To review key prognostic factors influencing disease progression and malignant transformation in serous borderline tumors.
- To discuss the proposed pathway linking SBTs to low-grade serous carcinoma (LGSC).
Main Methods:
- Review of clinical and pathological risk factors for SBT progression.
- Analysis of molecular data including gene expression profiling and mutation status (KRAS, BRAF).
- Evaluation of the association between SBTs and de novo LGSC.
Main Results:
- Extraovarian disease is the most significant predictor of progression in SBTs.
- Progression typically results in low-grade serous carcinoma, with occasional transformation to high-grade carcinoma.
- Evidence supports a serous borderline - low-grade serous carcinoma pathway.
Conclusions:
- Understanding prognostic factors is crucial for managing serous borderline tumors.
- The proposed pathway provides insight into the pathogenesis of LGSC.
- Extraovarian spread is a critical factor determining patient outcomes.
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