Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein-protein Interfaces02:04

Protein-protein Interfaces

14.8K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.8K
Protein and Protein Structure02:15

Protein and Protein Structure

89.4K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
89.4K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

14.7K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.7K
What are Proteins?01:55

What are Proteins?

240.7K
Overview
240.7K
Protein Networks02:26

Protein Networks

4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K
Protein Families02:47

Protein Families

17.2K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
17.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibition and Formation of Amyloid Fibrils in the Bulk and at the Interface of Biomolecular Condensates.

Angewandte Chemie (International ed. in English)·2026
Same author

De novo design of peptides localizing at the interface of biomolecular condensates.

Nature communications·2026
Same author

Competition between protein-RNA clustering and phase separation drives re-entrant phase behavior of hnRNPA1.

Nature communications·2026
Same author

Refined <i>in vivo</i> model for bone regeneration: insights into scaffold architecture and porosity.

Frontiers in bioengineering and biotechnology·2026
Same author

Rational Design of Zwitterionic Polymers with Tunable Phase Separation Propensity.

Macromolecules·2026
Same author

Structural defects in amyloid-β fibrils drive secondary nucleation.

Nature communications·2026
Same journal

Biologically Relevant, Cationic Residues in Human Rhinovirus Stabilize Capsid-Bound RNA Duplexes, and Restrict Capsid Flexibility.

Journal of molecular biology·2026
Same journal

Cryo-EM structures of phage T4 infection intermediate.

Journal of molecular biology·2026
Same journal

A classic fold with a twist: Structural architecture of Dhillonvirus phage Bas18.

Journal of molecular biology·2026
Same journal

Tesorai Search: cloud-based database search engine boosts identifications for mass spectrometry proteomics with a pretrained peptide-spectrum deep-learning model.

Journal of molecular biology·2026
Same journal

Characterization of diverse functions of NRF1 nuclear localization sequence.

Journal of molecular biology·2026
Same journal

UPF3A and UPF3B shape the transcriptome cooperatively yet oppose cell function.

Journal of molecular biology·2026
See all related articles

Related Experiment Video

Updated: Feb 16, 2026

Microfluidic Mixers for Studying Protein Folding
12:42

Microfluidic Mixers for Studying Protein Folding

Published on: April 10, 2012

15.6K

Microfluidics for Protein Biophysics.

Jérôme Charmet1, Paolo Arosio1, Tuomas P J Knowles2

  • 1Chemistry Department, University of Cambridge, Lensfield Road, Cambridge, CB3 0FF, UK.

Journal of Molecular Biology
|January 1, 2018
PubMed
Summary
This summary is machine-generated.

Microfluidics advances protein biophysics research by enabling novel applications beyond small volumes. This review highlights how microfluidic control and integration create new possibilities for studying protein structure and function.

Keywords:
microfluidicsprotein biophysics

More Related Videos

Recombinant Protein Expression, Crystallization, and Biophysical Studies of a Bacillus-conserved Nucleotide Pyrophosphorylase, BcMazG
12:23

Recombinant Protein Expression, Crystallization, and Biophysical Studies of a Bacillus-conserved Nucleotide Pyrophosphorylase, BcMazG

Published on: May 16, 2017

8.0K
High-throughput Protein Expression Generator Using a Microfluidic Platform
09:26

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

12.3K

Related Experiment Videos

Last Updated: Feb 16, 2026

Microfluidic Mixers for Studying Protein Folding
12:42

Microfluidic Mixers for Studying Protein Folding

Published on: April 10, 2012

15.6K
Recombinant Protein Expression, Crystallization, and Biophysical Studies of a Bacillus-conserved Nucleotide Pyrophosphorylase, BcMazG
12:23

Recombinant Protein Expression, Crystallization, and Biophysical Studies of a Bacillus-conserved Nucleotide Pyrophosphorylase, BcMazG

Published on: May 16, 2017

8.0K
High-throughput Protein Expression Generator Using a Microfluidic Platform
09:26

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

12.3K

Area of Science:

  • Life Sciences
  • Protein Biophysics
  • Microfluidics

Background:

  • Microfluidics offers transformative potential for experimental approaches in life sciences.
  • Conventional microfluidics is known for low-volume and short time-scale analysis.

Purpose of the Study:

  • To review recent advances in protein biophysics enabled by microfluidic technology.
  • To explore how microfluidics offers advantages beyond conventional applications.

Main Methods:

  • Discussion of single-phase laminar flow and multiphase microfluidics.
  • Exploration of microfluidic regime features, integration with orthogonal systems, and microenvironment generation.

Main Results:

  • Microfluidics enables novel devices and methods for protein biophysics.
  • Key features of microfluidics unlock new possibilities for protein analysis.
  • Applications include sample manipulation, structural and functional studies, detection, and material processing.

Conclusions:

  • Microfluidics provides powerful tools for advancing protein biophysics.
  • Understanding and controlling microfluidic systems is crucial for developing novel applications.
  • The integration of microfluidics with other systems enhances its utility in life science research.