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Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster
Published on: March 14, 2019
New advances in CNS immunity against viral infection
Monica Manglani1, Dorian B McGavern2
1Viral Immunology & Intravital Imaging Section, National Institute of Neurological Disorders & Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA; Medical Scientist Training Program, Pennsylvania State College of Medicine, Hershey, PA, USA.
Abstract:
The central nervous system (CNS) is an immunologically specialized organ where restrictive barrier structures protect the parenchyma from inflammation and infection. This protection is important in preventing damage to non-renewable resident cell populations, such as neurons, responsible for functions ranging from executive to autonomic. Despite these barriers, the CNS can be infected through several entry portals, giving rise to meningitis and encephalitis. Following infection, resident cells recruit peripherally derived immune cells to sites of viral infection. In this review, we discuss recent advances in immune recruitment and entry at barrier structures as well as current immunotherapeutic strategies for the treatment of persistent viral infections.
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