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Gender disparity in pediatrics: a review of the current literature

Paola Piccini1, Carlotta Montagnani2, Maurizio de Martino3

  • 1Post Graduate Pediatric School, University of Florence, Anna Meyer Children's University Hospital, viale Gaetano Pieraccini 24, I-50139, Florence, Italy.

Italian Journal of Pediatrics
|January 3, 2018
PubMed

Insights

Pediatric gender medicine research is limited, with few studies exploring the reasons for observed differences in children. More investigation into pharmacokinetic and pharmacodynamic variations between boys and girls is needed.

Area of Science:

  • Biomedical Research
  • Pediatric Medicine
  • Gender-Based Medicine

Background:

  • Gender-based medicine offers a novel perspective for health research.
  • Extensive research exists on adult gender medicine, but pediatric data is scarce.
  • Understanding sex-based differences is crucial for advancing child health.

Purpose of the Study:

  • To review existing literature on gender differences in pediatric medicine.
  • To identify research gaps in pediatric gender-based medicine.
  • To highlight the need for further investigation into sex-based variations in children's health.

Main Methods:

  • A comprehensive literature search was conducted on the PubMed database.
  • Articles published between July 2006 and February 2017 were reviewed.
  • The search focused on pediatric disorders across various medical fields, including endocrine, neurological, and immunological conditions.

Main Results:

  • Most studies focused on gender disparities in endocrine and neuro-psychiatric disorders in children.
  • Limited research exists on gender differences in gastrointestinal, immunological, oncological, rheumatic, and pneumological conditions.
  • Data on pharmacokinetic and pharmacodynamic differences between genders in children is notably absent.

Conclusions:

  • While pediatric gender differences are documented, the underlying reasons remain largely unexplored.
  • There is a significant lack of data regarding pharmacokinetic and pharmacodynamic variations between boys and girls.
  • Further research is essential to investigate these sex-based differences in childhood to advance personalized medicine.
Abstract

Keywords:
ChildrenGenderPediatrics

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