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Cardiometabolic Comorbidities in Psoriasis and Psoriatic Arthritis

Lluís Puig1

  • 1Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí 89, 08041 Barcelona, Spain. lpuig@santpau.cat.

International Journal of Molecular Sciences
|January 4, 2018
PubMed

Insights

Psoriasis and psoriatic arthritis (PsA) are linked to increased cardiovascular disease risk due to chronic inflammation. Anti-inflammatory treatments may offer cardiovascular protection for patients with these conditions.

Area of Science:

  • Rheumatology
  • Cardiology
  • Dermatology

Background:

  • Psoriasis and psoriatic arthritis (PsA) are associated with significant cardiovascular risk.
  • Chronic inflammation in PsA shares pathways with cardiovascular disease, contributing to comorbidities.

Purpose of the Study:

  • Review the epidemiology and mechanisms of cardiovascular disease in psoriasis/PsA patients.
  • Evaluate biomarkers for atherosclerosis and endothelial dysfunction in this population.
  • Examine evidence for cardioprotective effects of anti-inflammatory treatments in psoriasis/PsA.

Main Methods:

  • Literature review of epidemiological studies.
  • Analysis of mechanisms linking inflammation to cardiovascular risk.
  • Assessment of diagnostic tools and clinical trial data.

Main Results:

  • Strong epidemiological links between psoriasis/PsA and cardiovascular risk factors/disease.
  • Inflammation is a key shared pathway for comorbidities.
  • Emerging evidence supports cardioprotective roles for specific treatments.

Conclusions:

  • Psoriasis and PsA patients face elevated cardiovascular risks.
  • Understanding shared inflammatory pathways is crucial.
  • Targeted anti-inflammatory therapies may mitigate cardiovascular complications.

Keywords:
atherosclerosiscardiovascular diseasecardiovascular riskinflammationmetabolic syndromepsoriasispsoriatic arthritis

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