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Analytical models for time-domain diffuse correlation spectroscopy for multi-layer and heterogeneous turbid media.
Jun Li1,2,3, Lina Qiu4,3, Chien-Sing Poon2
1Guangdong Provincial Key Laboratory of Optical Information Materials and Technology, National Center for International Research on Green Optoelectronics, MOE International Laboratory for Optical Information Technologies, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, 510006, China.
Biomedical Optics Express
|January 4, 2018
Summary
This study introduces new analytical models for time-domain diffuse correlation spectroscopy (TD-DCS) to measure tissue optical and dynamic properties. TD-DCS shows enhanced sensitivity for deeper tissue analysis compared to CW-DCS.
Area of Science:
- Biomedical Optics
- Photonics
- Biophysics
Background:
- Diffuse Correlation Spectroscopy (DCS) measures dynamic properties of scattering media.
- Time-domain DCS (TD-DCS) offers simultaneous optical and dynamic property measurements.
- Accurate analytical models are crucial for interpreting TD-DCS data.
Purpose of the Study:
- To present analytical models for the time-resolved electric-field autocorrelation function in multi-layer and semi-infinite turbid media.
- To validate these models using Monte Carlo simulations.
- To compare the sensitivity of TD-DCS with continuous-wave (CW) DCS for deep tissue dynamics.
Main Methods:
- Development of analytical models for time-resolved autocorrelation functions.
- Monte Carlo simulations for model verification.
- Theoretical comparison of TD-DCS and CW-DCS sensitivity.
Main Results:
- Analytical models for TD-DCS were developed and validated against Monte Carlo simulations.
- High consistency between theoretical predictions and simulation results was achieved.
- TD-DCS demonstrated superior sensitivity for detecting deeper tissue dynamics compared to CW-DCS.
Conclusions:
- The validated analytical models are suitable for quantifying optical and dynamic properties from TD-DCS experiments.
- These models can aid in optimizing experimental designs for enhanced deep tissue contrast.
- The findings support the advancement of TD-DCS for in-vivo biomedical applications.
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