Related Experiment Video
Updated: Feb 16, 2026

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
Published on: August 25, 2022
Expression of focal adhesion genes in mesenchymal stem cells under simulated microgravity
A Yu Ratushnyy1, L B Buravkova2
1Institute for Biomedical Problems, Russian Academy of Sciences, Khoroshevskoe sh. 76a, Moscow, 123007, Russia.
Abstract:
The expression of 84 focal adhesion genes of multipotent mesenchymal stromal cells (MMSCs) after 96-h microgravity simulation at 3D clinorotation was studied. The upregulation of ITGA6, ITGA7, BCAR1, GRB2, CAV1, and DIAPH1 and the downregulation of ITGA11, ITGAV, ITGB1, PTEN, PTK2 (FAK), ARHGAP5, DOCK1, ROCK2, and AKT3 was found. These changes at the transcriptional level may be a cause of the reduction of the osteogenic potential of MMSCs and their ability to migration and adhesion in microgravity.
More Related Videos
Related Concept Videos
Intracellular Signaling Affects Focal Adhesions
Some...
Cell Specific Gene Expression
Cell Specific Gene Expression
Mesenchymal Stem Cells
What is Gene Expression?
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
What is Gene Expression?

