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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
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Human Multipotent Mesenchymal Stromal Cells Exhibit Resistance to Long-Term Simulated Microgravity.

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  • 1Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia. eagolikovamsu@gmail.com.

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Summary

Simulated microgravity alters human mesenchymal stromal cells (MSCs) by changing gene expression and increasing inflammatory cytokines, without affecting cell viability. These MSCs can model microgravity adaptation for spaceflight research.

Keywords:
simulated microgravity (SMG)umbilical cord tissue-derived mesenchymal stromal cells (UC-MSCs)

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Area of Science:

  • Space Biology
  • Cell Biology
  • Biomedical Research

Background:

  • Mesenchymal stromal cells (MSCs) are crucial for tissue repair and immune modulation.
  • Understanding cellular responses to microgravity is vital for long-duration space missions.

Purpose of the Study:

  • To investigate the functional and molecular changes in human umbilical cord-derived MSCs (UC-MSCs) under simulated microgravity.
  • To assess the potential of UC-MSCs as a model for studying microgravity adaptation.

Main Methods:

  • UC-MSCs were cultured for 30 days under simulated microgravity conditions.
  • Gene expression analysis was performed for stromal markers, cell cycle regulators, cytoskeletal genes, and adhesion molecules.
  • Cell viability and cytokine secretion were measured.

Main Results:

  • Simulated microgravity altered the expression of stromal markers and cell cycle regulators in UC-MSCs.
  • Cell viability and cytoskeletal gene expression remained unchanged.
  • Expression of adhesion molecules shifted, and secretion of proinflammatory cytokines increased.

Conclusions:

  • Microgravity significantly modulates the functional properties of UC-MSCs.
  • UC-MSCs serve as a viable model system for exploring molecular mechanisms of microgravity adaptation relevant to spaceflight.