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Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

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Published on: March 14, 2014

Prostate cancer grading: a decade after the 2005 modified system.

Jonathan I Epstein^1,2,3

¹Department of Pathology, The Johns Hopkins Medical Institution, Baltimore, MD, USA.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc

|January 4, 2018

Summary

The Gleason grading system for prostate cancer has evolved significantly, leading to a more patient-centric approach. This updated system, accepted by major pathology organizations, improves accuracy in diagnosing and managing prostate cancer.

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Area of Science:

Uropathology
Oncology
Cancer Grading Systems

Background:

The Gleason grading system, established in the 1960s-1970s, has been the standard for prostate cancer grading.
Significant advancements and multi-institutional validation have led to revisions and a more refined approach.

Purpose of the Study:

To review the historical evolution of prostate cancer grading systems.
To detail the development and acceptance of a new, patient-centric grading system.
To cover key aspects of Gleason grading, including variants and reporting rules.

Main Methods:

Review of historical data and seminal publications on prostate cancer grading.
Analysis of findings from the 2005 and 2014 International Society of Urological Pathology (ISUP) Grading Conferences.
Examination of reporting guidelines and applications of the Gleason system in clinical practice.

Main Results:

The Gleason system has undergone substantial evolution, culminating in a patient-centric approach proposed in 2013 and validated in 2014.
This revised system has been adopted by the World Health Organization (WHO), College of American Pathologists (CAP), and the AJCC TNM system.
The review covers Gleason patterns, grading variants, reporting rules, and applications in needle biopsies and radical prostatectomy specimens.

Conclusions:

The evolution of the Gleason grading system reflects a move towards more precise and patient-focused prostate cancer management.
The updated grading system, incorporating new approaches and reporting rules, enhances diagnostic accuracy and clinical utility.
Understanding the nuances of Gleason grading is crucial for accurate prostate cancer diagnosis and treatment planning.