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Updated: Feb 16, 2026
08:38
Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
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Tacrolimus - Pharmacokinetic Considerations for Clinicians.
Katharina Schutte-Nutgen1, Gerold Tholking1, Barbara Suwelack1
1Department of Medicine D, University of Munster, Munster, Germany.
Current Drug Metabolism
|January 5, 2018
Summary
Tacrolimus (Tac) blood concentration normalized by dose (C/D ratio) helps classify patients post-transplant. This C/D ratio is linked to patient outcomes, aiding in managing immunosuppressive therapy.
Area of Science:
- Pharmacology
- Transplantation Medicine
- Clinical Chemistry
Background:
- Tacrolimus (Tac) is a key immunosuppressant after renal transplantation (RTx).
- Managing Tac therapy is complex due to its narrow therapeutic window and variable metabolism.
- Therapeutic drug monitoring is essential for dose adjustment.
Purpose of the Study:
- To classify patients based on Tac metabolism using the C/D ratio.
- To investigate the association between the C/D ratio and transplant outcomes.
Main Methods:
- Calculation of the C/D ratio (blood concentration normalized by dose).
- Classification of patients into two major Tac metabolism groups.
- Statistical analysis of C/D ratio association with transplant outcomes.
Main Results:
- Patients receiving Tac can be categorized into two main metabolism groups based on the C/D ratio.
- The C/D ratio significantly correlates with renal outcomes in kidney and liver transplant recipients.
Conclusions:
- The C/D ratio is a valuable tool for understanding Tac metabolism and predicting transplant outcomes.
- Findings are relevant for transplant physicians managing immunosuppressive therapy.
- Review covers Tac pharmacokinetics, genetics, formulations, and clinical implications.
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