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Reference ranges for rotational thromboelastometry in male Sprague Dawley rats
Mariana Vigiola Cruz1,2,3, Jenna N Luker1, Bonnie C Carney1
1Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC USA.
Thrombosis Journal
|January 5, 2018
Summary
This study establishes reference ranges for rat coagulation parameters using the ROTEM® delta hemostasis analyzer. These findings aid in identifying coagulopathies in future rat studies.
Area of Science:
- Veterinary Hematology
- Hemostasis Research
- Rodent Models
Background:
- Investigating the extrinsic pathway of coagulation in Sprague Dawley rats.
- Utilizing citrated whole blood samples and a mini cup and pin system for functional coagulation assays.
Purpose of the Study:
- To establish reference ranges for coagulation parameters in healthy adult male Sprague Dawley rats.
- To provide a baseline for identifying coagulopathies in rat models.
Main Methods:
- Employing the ROTEM® delta hemostasis analyzer with the EXTEM test.
- Analyzing data from forty-three healthy adult male Sprague Dawley rats.
Main Results:
- Determined reference ranges (2.5-97.5 percentiles) for key coagulation parameters.
- Established ranges include CT [18-77], CFT [20-80], α [73-86], MCF [53-70], and ML [1-22].
- Provided comprehensive coagulation profiles for the study population.
Conclusions:
- The established reference ranges are crucial for future research involving rat coagulation.
- These ranges will facilitate the accurate identification of clinically significant coagulopathies in rats.
- This study provides a valuable resource for toxicological and pharmacological research in rats.
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