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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
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18F-Fluorodeoxyglucose PET/CT and dynamic contrast-enhanced MRI as imaging biomarkers in malignant pleural

David O Hall1,2, Clare E Hooper3,4,5, Julie Searle1,6

  • 1Cobalt Health, Cobalt Imaging Centre, Cheltenham.

Nuclear Medicine Communications
|January 5, 2018
PubMed
Abstract

Insights

Fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT and dynamic contrast-enhanced (DCE) MRI both offer prognostic information for malignant pleural mesothelioma. However, neither imaging technique is effective for monitoring disease progression during treatment.

Area of Science:

  • Oncology
  • Radiology
  • Nuclear Medicine

Background:

  • Malignant pleural mesothelioma is an aggressive cancer with limited treatment options.
  • Accurate prognostic and monitoring tools are crucial for optimizing patient management.

Purpose of the Study:

  • To compare fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT and dynamic contrast-enhanced (DCE) MRI for predicting prognosis and monitoring treatment response in malignant pleural mesothelioma.
  • To evaluate the utility of specific imaging metrics from both modalities in relation to patient survival and disease progression.

Main Methods:

  • Utilized data from the South West Area Mesothelioma Pemetrexed trial, including F-FDG PET/CT and DCE-MRI scans before and after chemotherapy.
  • Analyzed baseline imaging measurements (e.g., SUVmax, MTV, TLG for PET/CT; curve shape, washout for DCE-MRI) against overall survival (OS) using Kaplan-Meier and Cox regression.
  • Assessed changes in imaging measurements for correlation with progression-free survival.

Main Results:

  • F-FDG PET/CT and DCE-MRI measurements were not significantly correlated with each other.
  • Key F-FDG PET/CT metrics (SUVmax, MTV, TLG) and DCE-MRI washout curve shape were significantly associated with OS.
  • Combining DCE-MRI curve shape with F-FDG PET/CT provided additional prognostic value.
  • Changes in imaging measurements did not correlate with progression-free survival.

Conclusions:

  • Both F-FDG PET/CT and DCE-MRI provide valuable prognostic information in malignant pleural mesothelioma.
  • Neither imaging modality is suitable for monitoring disease progression during treatment.
  • Further research may explore combined imaging approaches for improved prognostic assessment.

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