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Published on: June 30, 2011
Association between Insulin-Like Growth Factor-1 and Frailty among Older Adults
T Doi1, H Makizako, K Tsutsumimoto
1Takehiko Doi, Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430, Morioka, Obu, Aichi 474-8511, Japan, Tel.: +81-562-44-5651, Fax: +81-562-46-8294,
Objectives:
Frailty is a course experienced in advanced aging. Identification of a biological factor associated with frailty is required. Although serum insulin-like growth factor-1 (IGF-1) is a potential factor related with frailty, consensus has not been reached regarding this relationship. This study aimed to investigate the association between IGF-1 and frailty in older adults.
Design:
Cross-sectional study.
Setting:
Cohort study that was part of the "National Center for Geriatrics and Gerontology - Study of Geriatric Syndromes."
Participants:
The study participants were 4133 older adults (mean age, 71.8 ± 5.4 years).
Measurements:
We assessed serum IGF-1 levels and frailty status and collected demographic variables, including cognitive function, as covariates.
Results:
Frailty and pre-frailty were present in 274 subjects (7%) and 1930 subjects (47%), respectively. Subjects were divided into four groups based on quartiles of IGF-1 levels. Multinomial logistic analysis showed that the lowest group had significant odds of pre-frailty (crude model: odds ratio [OR] 1.58, 95% confidence interval [CI] 1.30-1.90, p < .001; adjusted model: OR 1.38, 95% CI 1.13-1.68, p = .002) and frailty (crude model: OR 3.42, 95% CI 2.38-4.92, p < .001; adjusted model: OR 1.54, 95% CI 1.02-2.32, p = .039), compared with the highest group.
Conclusion:
Lower serum IGF-1 levels were independently related with frailty in older adults.
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