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Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
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Biotinylated Cyclooligosaccharides for Paclitaxel Solubilization.

Eunae Cho1, Seunho Jung2

  • 1Institute for Ubiquitous Information Technology and Applications (UBITA) & Center for Biotechnology Research in UBITA (CBRU), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea. echo@konkuk.ac.kr.

Molecules (Basel, Switzerland)
|January 6, 2018
PubMed
Summary

Researchers improved paclitaxel solubility using biocompatible cyclic carbohydrates. Biotinylated cyclosophoroses (CyS) and beta-cyclodextrins (β-CD) enhanced paclitaxel delivery for cancer therapy.

Keywords:
biotincyclooligosaccharidepaclitaxelsolubilization

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Area of Science:

  • Carbohydrate Chemistry
  • Drug Delivery Systems
  • Biotechnology

Background:

  • Paclitaxel, a vital chemotherapy drug, suffers from poor water solubility, hindering effective formulation and delivery.
  • Biocompatible cyclic carbohydrates offer potential solutions for solubilizing hydrophobic drugs.
  • Cyclosophoroses (CyS) and beta-cyclodextrins (β-CD) are cyclic oligosaccharides with unique structural properties.

Purpose of the Study:

  • To enhance the aqueous solubility and delivery of paclitaxel using modified cyclic carbohydrates.
  • To investigate the efficacy of biotinylated cyclosophoroses (CyS) and beta-cyclodextrins (β-CD) in paclitaxel solubilization.
  • To explore the potential of these modified carbohydrates as drug delivery vehicles for cancer therapeutics.

Main Methods:

  • Preparation and purification of bio-sourced cyclosophoroses (CyS) from Rhizobium leguminosarum.
  • Synthesis of beta-cyclodextrin (β-CD) and modification of both CyS and β-CD with biotin using N-hydroxysuccinimide ester of biotinamidohexanoic acid.
  • Quantification of paclitaxel aqueous solubility in the presence of biotinylated CyS and biotinylated β-CD.

Main Results:

  • Paclitaxel solubility was significantly increased by 10.3-fold with biotinyl CyS.
  • Paclitaxel solubility showed a 3.7-fold enhancement with biotinyl β-CD.
  • Biotinylation of cyclic carbohydrates effectively improved paclitaxel's aqueous solubility.

Conclusions:

  • Biotin-appended cyclooligosaccharides, specifically CyS and β-CD, are effective in enhancing paclitaxel's aqueous solubility.
  • These modified carbohydrates show promise as novel drug delivery systems for improving paclitaxel efficacy in cancer treatment.
  • The study highlights a viable strategy for overcoming solubility challenges in hydrophobic anticancer drug formulation.