Novel Blend for Producing Porous Chitosan-Based Films Suitable for Biomedical Applications
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Published on: February 6, 2016
Norhan Nady1,2, Sherif H Kandil3
1Chemical and Petrochemicals Engineering Department, Energy, Egypt-Japan University for Science and Technology, Alexandria 21934, Egypt. norhan.nay77@yahoo.com.
Abstract:
In this work, a chitosan-gelatin-ferulic acid blend was used in different ratios for preparing novel films that can be used in biomedical applications. Both acetic and formic acid were tested as solvents for the chitosan-gelatin-ferulic acid blend. Glycerol was tested as a plasticizer. The thickness, mechanical strength, static water contact angle and water uptake of the prepared films were determined. Also, the prepared films were characterized using different analysis techniques such as Fourier transform infrared spectroscopy (FT-IR) analysis, X-ray diffraction (XRD), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). Acetic acid produced continuous compact surfaces that are not recommended for testing in biomedical applications. The plasticized chitosan-gelatin-ferulic acid blend, using formic acid solvent, produced novel hexagonal porous films with a pore size of around 10-14 µm. This blend is recommended for preparing films (scaffolds) for testing in biomedical applications as it has the advantage of a decreased thickness.
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Ions as Acids and Bases
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
Bronsted-Lowry Acids and Bases

