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Updated: Feb 16, 2026
10:12
Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
Published on: April 4, 2014
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Catalytic asymmetric enamine protonation reaction
Niankai Fu1, Long Zhang, Sanzhong Luo
1Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China. luosz@iccas.ac.cn.
Organic & Biomolecular Chemistry
|January 6, 2018
Summary
Enantioselective protonation creates chiral centers using enamine catalysis. This review covers recent advances in synthesizing optically active carbonyl compounds via this method.
Area of Science:
- Organic Chemistry
- Catalysis
- Stereochemistry
Background:
- Enantioselective protonation is key for creating chiral tertiary carbon stereocenters.
- Enamine catalysis has emerged as a powerful strategy for asymmetric synthesis.
Purpose of the Study:
- To review recent advancements in enantioselective enamine protonation.
- To highlight the synthesis of optically active carbonyl compounds using this approach.
Main Methods:
- Enamine catalysis for enantioselective protonation.
- Dynamic kinetic resolution of alpha-substituted carbonyl compounds.
Main Results:
- Enamine catalysis enables efficient enantioselective protonation.
- Optically active carbonyl compounds can be synthesized with high enantiomeric purity.
Conclusions:
- Enantioselective enamine protonation is a versatile method for chiral synthesis.
- Further development in this field promises new avenues for asymmetric transformations.
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