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Related Experiment Video

Updated: Feb 16, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Aripiprazole-Loaded Polymeric Micelles: Fabrication, Optimization and Evaluation using Response Surface Method.

Payal H Patil¹, Pooja R Wankhede¹, Hitendra S Mahajan²

¹H.R. Patel Institute of Pharmaceutical Education and Research, Near Karwand Naka, Shirpur, Dist-Dhule, Maharashtra, India.

Recent Patents on Drug Delivery & Formulation

|January 6, 2018

Summary

This study developed Pluronic F127 micelles to enhance Aripiprazole solubility. The optimized Aripiprazole (ARP) micelles showed significantly improved drug release compared to the pure drug.

Keywords:

Aripiprazole amphiphilic copolymers pluronic F127 polymeric micelles response surface method solubility.

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Last Updated: Feb 16, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

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Published on: August 28, 2015

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

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Published on: June 8, 2016

Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Area of Science:

Pharmaceutical Sciences
Materials Science
Drug Delivery Systems

Background:

Aripiprazole (ARP) exhibits poor aqueous solubility, limiting its therapeutic efficacy.
Recent patents highlight the potential of Aripiprazole and Pluronic F127 micelles in pharmaceutical formulations.

Purpose of the Study:

To encapsulate Aripiprazole (ARP) within Pluronic F127 micelles to enhance its aqueous solubility.
To optimize the micellar formulation for improved drug delivery.

Main Methods:

Fabrication of Aripiprazole-loaded Pluronic F127 micelles using thin-film hydration.
Optimization of micellar formulation via response surface methodology (RSM).
Characterization using PDI, zeta potential, DLC, EE, in vitro drug release, DSC, FT-IR, P-XRD, TEM, and DLS.

Main Results:

Optimized conditions yielded micelles with PDI of 0.228, zeta potential of -4.04 mV, DLC of 76.50%, and EE of 18.56%.
In vitro studies demonstrated ~97% Aripiprazole release from micelles within 20h, thrice that of the pure drug.
TEM and DLS confirmed spherical micelles with a hydrodynamic diameter of 170.3 nm.

Conclusions:

The developed Pluronic F127 micellar system effectively enhances Aripiprazole solubility.
This polymeric micellar system shows significant potential as a drug delivery carrier for Aripiprazole.