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Anterior Segment Parameters in Patients With Wilson Disease
Necip Kara, Sevim Ayca Seyyar, Oguzhan Saygili
1Gastroenterology, Gaziantep University School of Medicine, Gaziantep, Turkey.
Cornea
|January 6, 2018
Summary
Patients with Wilson disease (WD) show distinct anterior segment eye parameters compared to healthy individuals. These differences in corneal thickness, curvature, and anterior chamber depth highlight potential ocular manifestations of WD.
Area of Science:
- Ophthalmology
- Genetics
- Internal Medicine
Background:
- Wilson disease (WD) is a rare autosomal recessive genetic disorder.
- It leads to excessive copper accumulation in various organs, including the liver and brain.
- Ocular manifestations in WD are not fully understood, necessitating further investigation.
Purpose of the Study:
- To investigate and compare anterior segment parameters in patients diagnosed with Wilson disease.
- To identify potential ocular biomarkers associated with Wilson disease.
Main Methods:
- A cross-sectional study involving 22 patients with WD and 22 healthy controls.
- Comprehensive ophthalmic assessments including visual acuity, slit-lamp biomicroscopy, and fundus examination.
- Anterior segment parameters were precisely measured using the Sirius anterior segment analyzer system.
Main Results:
- Patients with WD exhibited significantly thinner central corneal thickness (522 ± 47 μm) compared to controls (568 ± 37 μm).
- Elevated mean flat and steep keratometry, anterior, and posterior corneal elevation values were observed in the WD group.
- Reduced anterior chamber depth and horizontal visible iris diameter were noted in patients with Wilson disease.
Conclusions:
- Wilson disease patients demonstrate significant alterations in key anterior segment parameters.
- These findings suggest that ocular anterior segment changes are a notable feature of Wilson disease.
- Further research can explore the clinical significance and diagnostic potential of these ocular findings in WD management.
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