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Updated: Feb 16, 2026
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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
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Alginate as a potential diphase solid dispersion carrier with enhanced drug dissolution and improved storage
Jian Guan1, Qiaoyu Liu1, Xiaofei Zhang1
1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Summary
Alginate effectively enhances drug dissolution and stability for poorly soluble drugs. This diphase solid dispersion carrier shows superior performance compared to existing systems, offering improved drug delivery potential.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Enhancing dissolution rate and stability of poorly soluble drugs is crucial for effective drug delivery.
- Biocompatible polymers are actively explored as carriers for solid dispersions.
Purpose of the Study:
- To investigate alginate as a diphase solid dispersion carrier for improving the dissolution rate and stability of BCS Class II drugs.
- To evaluate alginate-based solid dispersions using lovastatin and indomethacin as model drugs.
Main Methods:
- Preparation of solid dispersions via solvent evaporation.
- Characterization using Hansen solubility parameter, DSC, XRPD, polar microscopy, Raman mapping, and SEM.
- Assessment of dissolution rate and accelerated stability compared to HPMCAS systems.
Main Results:
- Optimal drug/alginate ratios were drug-dependent, influencing drug state and miscibility.
- Alginate significantly improved solid dispersion stability, outperforming HPMCAS-based systems.
- Microphase separation was identified as the cause for minor dissolution decrease post-stability testing.
Conclusions:
- Alginate is a promising diphase solid dispersion carrier for enhancing dissolution and storage stability of BCS Class II drugs.
- The study demonstrates alginate's potential for improved pharmaceutical formulations.
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