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Updated: Feb 16, 2026
05:16
Sleeve Gastrectomy in Mice using Surgical Clips
Published on: November 14, 2020
7.4K
Sleeve gastrectomy surgery: when 2 alcoholic drinks are converted to 4
María Belén Acevedo1, J Christopher Eagon2, Bruce D Bartholow3
1Department of Food Science and Human Nutrition, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois.
Summary
Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) significantly increase blood alcohol concentration (BAC) and intoxication. Breathalyzers are unreliable for measuring BAC after these bariatric surgeries.
Area of Science:
- Bariatric Surgery
- Pharmacokinetics
- Alcohol Metabolism
Background:
- Roux-en-Y gastric bypass (RYGB) is known to increase peak blood alcohol concentration (BAC).
- Studies on sleeve gastrectomy (SG) effects on alcohol pharmacokinetics are conflicting, with some showing no effect and others a heightened peak BAC.
- Previous studies relied on breathalyzers, which may not accurately reflect peak BAC.
Purpose of the Study:
- To evaluate the effect of sleeve gastrectomy (SG) on alcohol pharmacokinetics and subjective effects compared to Roux-en-Y gastric bypass (RYGB) and a presurgery group.
- To determine the reliability of breathalyzers in assessing BAC after gastric surgeries.
Main Methods:
- A prospective, nonrandomized trial involving women who underwent SG (n=11), RYGB (n=8), or were awaiting bariatric surgery (n=9).
- Alcohol challenge tests were conducted, with BAC measured by gas chromatography and estimated by breathalyzers at various time points after consuming standardized alcohol doses.
Main Results:
- Both SG and RYGB groups exhibited a faster increase and approximately a 2-fold higher peak BAC compared to the presurgery group (P<.001).
- Feelings of drunkenness were also heightened in the SG and RYGB groups.
- Breathalyzer estimations underestimated BAC by 27% and failed to capture peak BAC levels post-surgery.
Conclusions:
- Sleeve gastrectomy (SG), similar to RYGB, significantly alters alcohol response, leading to a faster and higher peak BAC.
- Breathalyzers are deemed invalid for assessing the pharmacokinetic effects of alcohol after gastric surgeries.
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