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Filovirus proteins for antiviral drug discovery: Structure/function of proteins involved in assembly and budding

Baptiste Martin1, Olivier Reynard2, Viktor Volchkov2

  • 1Laboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR7257 CNRS, Parc Scientifique de Luminy, Aix-Marseille Université, Marseille, France.

Antiviral Research
|January 7, 2018
PubMed

Insights

No approved treatments exist for Marburg or Ebola virus infections. This review focuses on viral proteins crucial for filovirus assembly and budding, exploring structural data and antiviral strategies to combat these deadly diseases.

Area of Science:

  • Virology
  • Structural Biology
  • Infectious Diseases

Background:

  • Marburg virus and Ebola virus infections are severe hemorrhagic fevers with no approved treatments.
  • Previous research explored filovirus surface glycoprotein and replication proteins.

Purpose of the Study:

  • To review viral proteins involved in filovirus assembly and budding.
  • To integrate structural features of these proteins with their function in the viral replication cycle.
  • To summarize novel antiviral strategies targeting filovirus assembly and egress.

Main Methods:

  • Review of available structural data for viral proteins associated with virus assembly and virion egress.
  • Integration of structural features into the functional context of the viral replication cycle.
  • Summary of recent advances in antiviral strategy development.

Main Results:

  • Detailed description of structural data for key viral assembly and egress proteins.
  • Functional context of these proteins within the filovirus replication cycle.
  • Identification of innovative antiviral targets.

Conclusions:

  • Understanding filovirus assembly and egress mechanisms is critical for developing effective treatments.
  • Targeting these processes offers promising avenues for prophylactic or post-exposure therapies.
  • Advancements in this area could aid in controlling future filovirus outbreaks.
Keywords:
Antiviral therapyEbola virusFilovirusMarburg virusMononegaviralesVirion assembly

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