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Area of Science:

  • Neuroscience
  • Psychiatry
  • Dermatology

Background:

  • Skin-picking disorder (SPD) is a prevalent mental health condition involving compulsive skin picking.
  • Existing models propose SPD may relate to pathological grooming triggered by perceived infection cues.
  • Empirical evidence for these models, particularly regarding disgust, remains limited.

Purpose of the Study:

  • To investigate the role of disgust processing in skin-picking disorder.
  • To examine neural correlates of disgust and urge to pick in SPD patients.
  • To explore personality traits associated with SPD, including self-loathing and disgust regulation.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to scan 25 women with SPD and 19 controls.
  • Participants viewed images of normal skin and skin irregularities.
  • Self-reported disgust, urge to pick, and personality traits were assessed.

Main Results:

  • SPD patients reported significantly higher disgust and urge to pick when viewing skin irregularities compared to controls.
  • fMRI data revealed greater activation in the insula and amygdala in SPD patients.
  • Enhanced insula-putamen connectivity was observed in SPD patients, correlating with disgust intensity.

Conclusions:

  • This study provides the first empirical evidence for altered disgust processing in individuals with skin-picking disorder.
  • Heightened disgust responses and associated neural activity (insula, amygdala, putamen) are implicated in SPD.
  • Difficulties in disgust regulation and elevated self-loathing may contribute to SPD pathology.