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Updated: Feb 16, 2026

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
Published on: June 18, 2018
Multiproteinopathy, neurodegeneration and old age: a case study
Julio C Rojas1, Melanie L Stephens1, Gil D Rabinovici1
1a Memory and Aging Center, Department of Neurology , University of California San Francisco , San Francisco, USA.
Abstract:
A complex spectrum of mixed brain pathologies is common in older people. This clinical pathologic conference case study illustrates the challenges of formulating clinicopathologic correlations in late-onset neurodegenerative diseases featuring cognitive-behavioral syndromes with underlying multiple proteinopathy. Studies on the co-existence and interactions of Alzheimer's disease (AD) with neurodegenerative non-AD pathologies in the aging brain are needed to understand the pathogenesis of neurodegeneration and to support the development of diagnostic biomarkers and therapies.
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