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Brain Waves01:23

Brain Waves

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Updated: Feb 16, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
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Brain metastases: radiosurgery.

Amparo Wolf1, Douglas Kondziolka1

  • 1Department of Neurosurgery, Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York University, New York, NY, United States.

Handbook of Clinical Neurology
|January 9, 2018
PubMed
Summary

Stereotactic radiosurgery (SRS) offers a minimally invasive approach for brain metastases, improving survival and local control. Combining SRS with systemic therapies enhances treatment efficacy for intracranial and extracranial disease.

Keywords:
brain metastasesgamma knife radiosurgeryimmunotherapyoverall survivalstereotactic radiosurgerytargeted therapytumor local control

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Brain metastases significantly impact patient outcomes and quality of life.
  • Traditional treatments for brain metastases include surgery and whole-brain radiation therapy, which can have significant toxicities.
  • Stereotactic radiosurgery (SRS) has emerged as a key modality in managing intracranial malignancies.

Purpose of the Study:

  • To review the role and efficacy of stereotactic radiosurgery in the management of brain metastases.
  • To highlight the benefits of SRS, including its precision, low toxicity, and effectiveness in cases with multiple metastases.
  • To discuss the integration of SRS with modern systemic therapies and advanced imaging for comprehensive cancer care.

Main Methods:

  • Review of randomized controlled trials and prospective studies evaluating SRS for brain metastases.
  • Analysis of treatment outcomes, including survival rates and local tumor control.
  • Assessment of SRS in conjunction with systemic therapies (chemotherapy, targeted therapy, immunotherapy).

Main Results:

  • SRS demonstrates a survival advantage and high local control rates for brain metastases, even with up to 10 lesions.
  • SRS is a minimally invasive alternative to surgical resection with reduced toxicity to surrounding brain tissue.
  • Concurrent administration of SRS with systemic therapies may yield additive or synergistic effects, accelerating treatment.

Conclusions:

  • Stereotactic radiosurgery is a cornerstone in the modern management of brain metastases.
  • Routine MRI surveillance in high-risk cancer patients facilitates early detection and prompt SRS treatment, preventing neurological deficits.
  • The combination of SRS with advanced systemic therapies represents a significant advancement in treating both intracranial and extracranial metastatic disease.