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Related Experiment Video

Updated: Feb 16, 2026

Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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Purification of Ubiquitinated p53 Proteins from Mammalian Cells

Published on: March 21, 2022

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p53 and reproduction.

Hey-Joo Kang1, Zev Rosenwaks1

  • 1The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.

Fertility and Sterility
|January 9, 2018
PubMed
Summary

Tumor protein 53 (TP53) and its family regulate cellular activity and tumor suppression. Polymorphisms in TP53 codon 72 influence reproduction and leukemia inhibitory factor expression.

Area of Science:

  • Molecular Biology
  • Genetics
  • Reproductive Biology

Background:

  • Tumor protein 53 (TP53) and its family members (p63, p73) are crucial tumor suppressors.
  • p53 regulates cellular activity, longevity, and DNA repair mechanisms against tumor growth.
  • The role of p53 in normal cellular processes and reproduction is less understood.

Purpose of the Study:

  • To review the function of p53 and its family proteins.
  • To explore the impact of TP53 polymorphisms on reproductive health.
  • To understand p53's role beyond tumor suppression.

Main Methods:

  • Literature review of studies on p53 family proteins.
  • Analysis of research on TP53 codon 72 polymorphisms in murine and human models.
  • Examination of gene expression related to TP53 variants.
Keywords:
in vitro fertilizationmiscarriagep53polymorphismreproduction

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Main Results:

  • TP53 codon 72 arginine variant shows higher apoptosis and leukemia inhibitory factor (LIF) expression.
  • TP53 codon 72 proline variant (C allele) reduces LIF expression.
  • p53 family members are vital for germ cell survival in both sexes.

Conclusions:

  • TP53 and its family play significant roles in cellular regulation and reproduction.
  • TP53 codon 72 polymorphisms may affect implantation and reproductive outcomes.
  • Further research is needed to fully elucidate p53's reproductive functions.