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Updated: Feb 16, 2026

Sulfate Separation by Selective Crystallization with a Bis-iminoguanidinium Ligand
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Mutual Impact of Phase Separation/Crystallization and Water Sorption in Amorphous Solid Dispersions

Christian Luebbert1, Maximilian Wessner1, Gabriele Sadowski1

  • 1Department of Biochemical and Chemical Engineering, Laboratory of Thermodynamics, TU Dortmund University , Emil-Figge-Straße 70, D-44227 Dortmund, Germany.

Molecular Pharmaceutics
|January 9, 2018
PubMed
Summary

Predicting water sorption in amorphous solid dispersions (ASDs) is crucial for stability. This study shows that crystallization and phase separation influence water uptake, and this behavior can be quantitatively predicted using PC-SAFT modeling.

Keywords:
PC-SAFTamorphous solid dispersionlong-term stabilitymoisture-induced amorphous−amorphous phase separationwater sorption

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