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Cellular immunity in human milk.

J R Oksenberg, E Persitz, C Brautbar

    American Journal of Reproductive Immunology and Microbiology : AJRIM
    |August 1, 1985
    PubMed
    Summary
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    Human milk lymphocytes (MIL) show reduced responses to some stimuli but can stimulate alloreactivity. Macrophages in milk effectively present antigens to T cells, highlighting their role in infant immunity.

    Area of Science:

    • Immunology
    • Neonatal Immunology

    Background:

    • Human milk contains lymphocytes (MIL) crucial for infant immunity.
    • Understanding MIL function is key to neonatal immune defense.

    Purpose of the Study:

    • To compare the functional responses of MIL and peripheral blood lymphocytes (PBL).
    • To investigate the antigen-presenting capacity of milk-derived macrophages.
    • To assess MIL responses to specific bacterial pathogens.

    Main Methods:

    • In vitro culture of MIL and PBL with mitogens and allogeneic cells.
    • Antigen presentation assays using milk macrophages and peripheral T cells.
    • Flow cytometry and antibody-mediated cell depletion.

    Main Results:

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  • MIL exhibited decreased proliferative responses to mitogens and allogeneic cells compared to PBL.
  • Milk macrophages effectively induced proliferation in peripheral blood T cells.
  • MIL showed differential responses to E. coli and Yersinia enterocolitica.
  • T cell and HLA class II antigen involvement was confirmed in MIL responses.

    • Conclusions:

    • MIL possess distinct functional characteristics compared to PBL.
    • Milk macrophages play a significant role in initiating adaptive immune responses in neonates.
    • MIL contribute to the neonate's defense against enteric pathogens.