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Updated: Feb 16, 2026
08:46
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
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Red cell distribution width and its association with mortality in neonatal sepsis
Snehal L Martin1, Saumil Desai2, Ruchi Nanavati2
1a Department of Haematogenetics , National Institute of Immunohaematology (ICMR), KEM Hospital campus , Mumbai , India.
Summary
Red cell distribution width (RDW) is higher in neonatal sepsis cases and predicts mortality. Elevated RDW levels (≥20%) in septic newborns indicate increased mortality risk, offering a new predictive marker.
Area of Science:
- Neonatology
- Hematology
- Critical Care Medicine
Background:
- Neonatal sepsis is a leading cause of death in developing nations.
- Current methods for predicting neonatal sepsis outcomes are challenging.
- Red cell distribution width (RDW) is a potential prognostic tool in various conditions but is unexplored in neonates.
Purpose of the Study:
- To investigate the association between Red cell distribution width (RDW) and neonatal sepsis.
- To evaluate RDW's utility as a predictive marker for mortality in neonatal sepsis.
Main Methods:
- A prospective observational study compared RDW in 251 septic neonates and 251 controls (>28 weeks gestational age).
- RDW was measured from complete blood counts within 6 hours of birth.
- Kaplan-Meier curves and log-rank tests assessed survival rates based on RDW levels (≥20% vs. <20%).
Main Results:
- Septic neonates exhibited significantly higher RDW levels (19.90%) compared to controls (18.90%) (p < .001).
- RDW was significantly higher in non-survivors than survivors (p < .003).
- Neonates with RDW ≥20% showed significantly increased mortality (p < .02).
Conclusions:
- Elevated Red cell distribution width (RDW) is significantly associated with neonatal sepsis.
- RDW serves as an independent predictor of mortality in neonatal sepsis.
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