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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Cognitive functioning in systemic lupus erythematosus: a meta-analysis.

B Leslie1, S F Crowe1

  • 197586 College of Science Health and Engineering, La Trobe University , School of Psychology and Public Health, Bundoora, Victoria, Australia.

Lupus
|January 10, 2018
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) patients often experience cognitive deficits, even without obvious neurological symptoms. This meta-analysis confirms small attention and memory impairments in SLE, with greater deficits in neuropsychiatric SLE (NPSLE).

Keywords:
Systemic lupus erythematosuscognitionneuropsychiatricneuropsychologyreview

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Area of Science:

  • Neuroscience
  • Rheumatology
  • Psychology

Background:

  • Cognitive deficits are prevalent in Systemic Lupus Erythematosus (SLE) patients.
  • A distinct neuropsychological profile for SLE remains unclear.
  • Neuropsychiatric involvement (NPSLE) may exacerbate cognitive issues.

Purpose of the Study:

  • To systematically review and meta-analyze cognitive alterations in SLE patients.
  • To identify a specific neuropsychological profile associated with SLE.
  • To compare cognitive function between NPSLE and non-NPSLE patients.

Main Methods:

  • Literature search of PubMed, Scopus, and Ovid (PsychINFO) databases.
  • Inclusion of studies using standardized neuropsychological (NP) measures.
  • Meta-analytical procedures to analyze collected data.

Main Results:

  • SLE patients show small effect-sized deficits in visual attention, fluency, immediate visual memory, and visual reasoning compared to controls.
  • Cognitive impairment follows a gradient, with NPSLE patients exhibiting greater deficits than non-NPSLE patients.
  • NPSLE patients have medium-sized deficits in complex attention, delayed verbal memory, language, and verbal reasoning.

Conclusions:

  • Cognitive deficits are a significant feature of SLE, irrespective of overt neuropsychiatric symptoms.
  • Neuropsychological assessment is crucial for understanding and managing SLE patients.
  • Findings inform assessment and rehabilitation strategies for SLE patients.