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Related Concept Videos

Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

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Updated: Jun 27, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Interictal Cognitive Deficits in Migraine Sufferers: A Meta-Analysis.

Dion L Braganza1, Lauren E Fitzpatrick1, Mai L Nguyen1

  • 1School of Psychology and Public Health, La Trobe University, Bundoora, VIC, 3086, Australia.

Neuropsychology Review
|August 16, 2021
PubMed
Summary
This summary is machine-generated.

Migraine patients show moderate cognitive deficits in attention, memory, spatial cognition, and executive functioning between attacks. These findings highlight potential interictal impairments in individuals with migraine.

Keywords:
AuraCognitionInterictalMeta-analysisMigraineNeuropsychology

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Area of Science:

  • Neuroscience
  • Cognitive Psychology

Background:

  • Migraine affects a significant population, yet objective cognitive deficits between acute attacks remain unclear.
  • Existing research lacks consensus on whether migraineurs experience persistent cognitive impairments.

Approach:

  • A quantitative meta-analysis synthesized data from 17 studies comparing cognitive function in migraineurs and healthy controls.
  • Searches included PubMed, Ovid MEDLINE, and PsycINFO (1980-2020), with prospective registration on PROSPERO.

Key Points:

  • Migraineurs exhibited moderate, negative effects on complex attention, immediate/delayed memory, spatial cognition, and executive functioning during interictal periods.
  • These cognitive effects were independent of migraine history, attack frequency, or participant age.
  • Potential confounds include lack of performance validity testing and limited data on mood and medication use.

Conclusions:

  • Migraine is associated with interictal cognitive deficits across multiple domains.
  • Further comprehensive neuropsychological research is recommended, controlling for potential confounds and using clinical control groups.