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Updated: Jun 19, 2026

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

Health Outcomes Following Traumatic Brain Injury: An Umbrella Review.

Jason M Toliao¹, Junhyuk Lee², Hans Oh³

¹University of Southern California, Los Angeles, CA, USA. jason_toliao@outlook.com.

Neuropsychology Review

|June 18, 2026

Summary

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Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

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This summary is machine-generated.

Traumatic brain injury (TBI) is linked to various health issues, including neurological and mental health problems. However, most existing research on TBI outcomes has critical quality limitations, hindering causal conclusions.

Area of Science:

Neuroscience
Public Health
Epidemiology

Background:

Traumatic brain injury (TBI) is a significant public health concern with numerous documented health outcomes.
Existing literature includes many systematic reviews and meta-analyses on TBI-associated comorbidities.
Evaluating the methodological rigor of this body of evidence is crucial for accurate interpretation.

Purpose of the Study:

To conduct an umbrella review of systematic reviews and meta-analyses on health outcomes following TBI.
To assess the association between TBI and comorbid health conditions.
To evaluate the methodological quality of the included literature using AMSTAR2 criteria.

Main Methods:

Systematic search of EMBASE, PubMed, MEDLINE, and Cochrane Library up to November 26, 2025.

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Controlled Cortical Impact Model for Traumatic Brain Injury

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

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Last Updated: Jun 19, 2026

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

Controlled Cortical Impact Model for Traumatic Brain Injury

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

Inclusion of meta-analyses of observational studies reporting effect sizes convertible to odds ratios.

Application of PRISMA guidelines for study formatting and AMSTAR2 for quality assessment.

Main Results:

41 meta-analyses, encompassing 671 studies and 83 million participants, were included.
TBI is associated with impairments in neurological, sleep, cognitive, mental health, and behavioral domains.
A significant majority (78%) of included studies were rated as having critically low methodological quality.

Conclusions:

TBI, regardless of age of onset, is associated with a wide spectrum of adverse health outcomes.
The methodological limitations in the existing literature restrict the ability to establish causal relationships.
Further research with improved frameworks is necessary to elucidate the long-term consequences of TBI.