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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Related Experiment Video

Updated: Jun 18, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Understanding DMG: current treatment options and prospective solutions using nanoparticles.

Ahmed Mohamed1,2, Aleksey Lyzlov2,3, Rachna Prasad4

  • 1University of Central Florida College of Medicine, Orlando, FL, USA.

Drug Delivery and Translational Research
|June 17, 2026
PubMed
Summary

Nanoparticles offer new ways to treat Diffuse Midline Gliomas (DMG) by improving drug delivery across the Blood-Brain Barrier (BBB). Further research is needed to overcome challenges for successful clinical use.

Keywords:
DIPGblood–brain barrierdiffuse midline gliomadrug deliverynanoparticlesneuro-oncologyradiosensitizationtheranostics

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Last Updated: Jun 18, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Area of Science:

  • Neuro-oncology
  • Nanomedicine
  • Biomaterials

Background:

  • Diffuse Midline Gliomas (DMG) have a very poor prognosis due to invasive nature, deep location, drug resistance, and a "cold" tumor microenvironment.
  • Limited Blood-Brain Barrier (BBB) penetration hinders conventional therapies for DMG.
  • Targetable molecular pathways in H3K27-altered DMG present opportunities for novel therapeutic strategies.

Purpose of the Study:

  • To review nanoparticle (NP) strategies for overcoming therapeutic challenges in Diffuse Midline Gliomas (DMG).
  • To evaluate NP platforms and design principles for enhanced drug delivery across the BBB.
  • To explore theranostic applications and radiosensitizing potential of NPs in DMG treatment.

Main Methods:

  • Review of nanoparticle platforms including liposomal, polymeric, inorganic, and carbon-based nanomaterials.
  • Analysis of NP design principles (size, charge, coating) for targeted delivery and BBB penetration.
  • Evaluation of theranostic applications and radiosensitizing properties of nanomaterials.

Main Results:

  • Nanoparticles show potential to enhance drug delivery across the BBB, concentrate therapy at the tumor site, and reduce systemic toxicity.
  • NP strategies can enable targeted, sustained, and image-guided therapy for DMG.
  • High-Z metal NPs can act as radiosensitizers, increasing tumor cell DNA damage.

Conclusions:

  • Nanomedicine offers adaptive solutions to critical barriers in Diffuse Midline Glioma (DMG) therapy.
  • Overcoming challenges in BBB penetration, distribution, and manufacturing is crucial for clinical translation.
  • Multidisciplinary research focusing on NP optimization, targeted delivery, theranostics, and scalable manufacturing is essential for improving patient survival.