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A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats
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Neonatal Abstinence Syndrome: Twins Case Series
Rajesh Pandey1, Narmada Pandey Sapkota2, Deepak Kumar3
1Department of Pediatrics, University of Texas, Health Science Center at Houston, Houston, TX, United States.
Frontiers in Pediatrics
|January 10, 2018
Summary
Twin studies suggest environmental factors may play a significant role in Neonatal Abstinence Syndrome (NAS) severity. Concordance in withdrawal severity between twins indicates a potential environmental influence on NAS development and progression.
Area of Science:
- Neonatalogy
- Genetics
- Perinatal Medicine
Background:
- Opioid use during pregnancy poses risks for maternal and neonatal health, including Neonatal Abstinence Syndrome (NAS).
- The relative contributions of genetic and environmental factors to NAS severity are not fully understood.
- Twin studies offer a unique model to investigate the heritability of complex conditions like NAS.
Observation:
- This case series reviewed outcomes for newborn twins exposed to substances, focusing on NAS severity.
- Seven sets of twins (one monozygotic, six dizygotic) were analyzed.
- NAS severity and treatment requirements were compared between co-twins.
Findings:
- Five of seven twin sets demonstrated concordance in NAS severity, with two sets showing discordance.
- Concordance in withdrawal severity suggests a potential environmental influence on NAS.
- The limited number of monozygotic twins restricts definitive conclusions on genetic roles.
Implications:
- Findings suggest environmental factors significantly influence NAS severity, warranting further investigation.
- Larger twin studies are needed to elucidate the interplay of genetic and environmental factors in NAS pathogenesis.
- Understanding these factors can inform targeted interventions and improve neonatal outcomes.
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